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Comprehensive analysis of clinical research and evidence*
Mood & Sleep Support By Menopause Science
Clinical research shows that up to 80% of perimenopausal women experience mood disturbances and sleep problems. Mood and Sleep Support provides organic ashwagandha root enhanced with black pepper extract for maximum bioavailability and effectiveness.*
Research Summary
Clinical research suggests that ashwagandha supplementation may significantly reduce perceived stress, anxiety, and improve sleep quality while supporting healthy cortisol levels. Studies specifically in perimenopausal women suggest that ashwagandha may reduce total menopause symptom scores, with particular benefits for psychological symptoms, mood disturbances, and sleep disruption. The addition of black pepper extract (piperine) may enhance absorption, potentially ensuring optimal therapeutic benefits.*
Research at a Glance
| Ingredient | Population Studied | Studied Benefit(s) | Research Link |
|---|---|---|---|
| Ashwagandha (600mg daily) | 100 perimenopausal women aged 45-60 | 8-week RCT: Significant reduction in total menopause symptoms, anxiety, irritability, and depressive symptoms vs placebo | View Study |
| Ashwagandha (300mg 2x daily) | 64 adults with chronic stress | 60-day RCT: 44% reduction in stress scores, significant reduction in anxiety and cortisol levels | View Study |
| Ashwagandha (240mg daily) | 60 stressed adults | 60-day RCT: Significant reduction in anxiety (HAM-A scale) and morning cortisol levels vs placebo | View Study |
| Ashwagandha | 400 participants across 5 studies | Meta-analysis: Significant improvement in overall sleep quality, sleep onset latency, and total sleep time | View Study |
| Ashwagandha (300mg 2x daily) | 60 insomnia patients | 10-week RCT: Significant improvement in sleep onset latency, sleep efficiency, and quality vs placebo | View Study |
| Black Pepper (Piperine) | Various supplement studies | Bioavailability enhancer: Increases absorption of herbal compounds by inhibiting liver enzymes | View Study |
Plain Language Summary
Ashwagandha has been studied in adults, including women going through perimenopause, for its potential role in reducing stress, supporting mood, and improving sleep. Several clinical trials suggest it may help lower perceived anxiety, support healthier cortisol levels, and improve sleep quality. When combined with black pepper extract, absorption may be enhanced, which could increase effectiveness.*
Key Citations
Primary Research in Perimenopausal Women:
- Gopal S, et al. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. J Obstet Gynaecol Res. 2021;47(12):4414-4425. PubMed: 34553463
Supporting Stress and Anxiety Research:
- Chandrasekhar K, et al. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-262. PubMed: 23439798
- Lopresti AL, et al. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract. Medicine. 2019;98(37):e17186. Medicine Journal
Sleep Research:
- Cheah KL, et al. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. PLoS One. 2021;16(9):e0257843. PubMed: 34559859
- Langade D, et al. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study. Cureus. 2019;11(9):e5797. PMC: 6827862
Bioavailability Enhancement Research:
- Dudhatra GB, et al. A comprehensive review on pharmacotherapeutics of herbal bioenhancers. ScientificWorldJournal. 2012;2012:637953. PMC: 3634921
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Shop NowThese statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult with your healthcare provider before starting any new supplement regimen, especially if you have pre-existing health conditions or are taking medications.
The research cited represents studies conducted on individual ingredients and may not reflect the specific formulation of this product. Individual results may vary based on sleep hygiene, stress levels, health status, and other factors. The research cited represents potential benefits and does not guarantee specific outcomes for all users.