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Comprehensive analysis of clinical research and evidence*
Biome Rebalance Formula By Menopause Science
Gut health isn’t optional. When your digestion is off, everything from bloating to energy and focus can feel harder. Biome Rebalance combines Birch Chaga and Pine Bark extract containing fulvic and humic acids—compounds that may help support healthy gut microbiome balance and digestive function. *
Research Summary
During menopause and perimenopause, changes in hormone levels can disrupt gut bacteria diversity, slow digestion, and impact nutrient absorption. Research suggests that fulvic acid may help modulate gut microbiota composition by promoting the growth of beneficial bacteria while supporting the intestinal barrier. Pine bark extract provides polyphenols that may further support digestive wellness and antioxidant activity. While limited menopause-specific gut health trials exist, studies in women and mixed populations suggest these compounds may help support digestive comfort, microbiome balance, and overall gastrointestinal wellness.*
Research at a Glance
| Ingredient | Population Studied | Studied Benefit(s) | Research Link |
|---|---|---|---|
| Fulvic acid (from humic substances) | Adults with inflammatory conditions | Review suggests potential to help modulate immune system and may support gastrointestinal function | View Study |
| Pine bark extract (Pycnogenol) | Women with menopausal symptoms | Multiple trials show antioxidant support and may help with digestive comfort | View Study |
| Pine bark extract polyphenols | Mixed adult population | In vitro studies suggest a positive influence on gut bacterial strains and microbiome balance. | View Study |
| Chaga mushroom extract | Mixed adult population | Review shows edible mushrooms may support gut microbiota diversity and beneficial bacteria growth | View Study |
Plain Language Summary
Hormonal changes during perimenopause and menopause can affect digestion. Many women report bloating, changes in bowel habits, and general digestive discomfort. While research is still emerging, supporting gut health is considered an important part of overall midlife wellness.*
How Gut Health Connects to Hormones
The gut microbiome plays a role in hormone metabolism and mood regulation. Ingredients such as fulvic acid have been studied for their ability to support beneficial bacteria, which may help maintain balance during hormonal transitions.*
Nutrient Absorption as the Body Changes
As metabolism shifts with age, efficient absorption of vitamins and minerals becomes increasingly important for energy, bone health, and overall vitality. Early research suggests fulvic acid may support digestive enzymes and nutrient uptake.*
Antioxidant Support for Comfort
Pine bark extract provides polyphenols, plant-based compounds that offer antioxidant support. This may help maintain a comfortable digestive environment, especially during times of hormonal stress.*
Traditional Wellness Ingredients
Chaga mushroom has a long history of traditional use for general wellness, including digestive health support.*
Key Citations
Primary Research on Fulvic Acid:
- Gandy JJ, et al. Therapeutic potential of fulvic acid in chronic inflammatory diseases and diabetes. PMC. 2018. PMC: 6151376
Pine Bark Extract Research:
- Pycnogenol® French maritime pine bark extract in randomized, double-blind, placebo-controlled human clinical studies. Front Nutr. 2024. PMC: 11096518
- Effect of pine bark extract and its phenolic compounds on selected pathogenic and probiotic bacterial strains. Front Nutr. 2024. Frontiers
Mushroom Gut Health Research:
- Jayachandran M, et al. A critical review on health-promoting benefits of edible mushrooms through gut microbiota. Int J Mol Sci. 2017. PMC: 5618583
End the Soap Opera in Your Gut
Targeted support to quiet the drama and keep things moving smoothly.
Shop NowThese statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult with your healthcare provider before starting any new supplement regimen, especially if you have pre-existing health conditions or are taking medications.
The research cited represents studies conducted on individual ingredients and may not reflect the specific formulation of this product. Individual results may vary based on sleep hygiene, stress levels, health status, and other factors. The research cited represents potential benefits and does not guarantee specific outcomes for all users.